The diamond bit matrix formulas are designed by uniform design with constraints to study the effects of diamond bit matrix formula on sharpness and life.Nonlinear regression analysis of experimental data is performed in SPSS to obtain the relationship between the performance and the component.At the same time,the sequence of influence factors and the significance are revealed using t test.Finally,the optimized formula is obtained through excel programming.The results show that the established Scheffe regression equation has a good fit to the experimental results.The content of Co element has a significant influence on the sharpness and life of diamond bit.The uniform design of the formula can reach desired result with less tests.