To optimize OD grinding cylindrical roller process, orthogonal experiment is designed on the influences of workpiece deflection angle, workpiece position and rotation speeds, namely rotation speed of both polishing disks, eccentric wheel and outer gear ring, on material removal rate, surface roughness and roundness. Results show that the angle has most significant effect on material removal rate, followed by rotation speeds and workpiece position. As with surface roughness, the sequence should be rotation speed, angle and position. Workpiece position influences the roundness most, then rotation speeds and angle. The best processing parameters are deflection angle 0°, workpiece position 0.8, and rotation spees of up & down polishing disks, eccentric wheel and outer gear ring are -76, 84, 80 and 48 r/min, respectively. After machining for 15 min, the material removal rate could reach 0.541 μm/min, with surface roughness from 0.078 to 0.045 μm, decreasing 42.3%, and roundness from 0.74 to 0.41 μm, decreasing 44.6%.